When A Dog Has One Blue Eye. But on average, all dogs have brown eyes. Heterochromia is caused by a lack of the pigment melanin . Genetic variants don't always affect both eyes. But on average, all dogs have brown eyes. Not only are these really pretty combinations, but they're also rare. A single blue eye is most common in huskies, australian shepherds, great danes, catahoula leopard .
An eye disease is any condition that affects the eye.
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