When A Dog Has One Blue Eye. But on average, all dogs have brown eyes. Heterochromia is caused by a lack of the pigment melanin . Heterochromia is caused by a lack of the pigment melanin . It not only occurs in dogs but also affects cats, horses and occasionally even people. Some dogs are born with one brown eye and one blue eye, which can look very strange since we're used to seeing dogs with two brown eyes. Genetic variants don't always affect both eyes. But on average, all dogs have brown eyes. Not only are these really pretty combinations, but they're also rare. A single blue eye is most common in huskies, australian shepherds, great danes, catahoula leopard .An eye disease is any condition that affects the eye.
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